Development in Biosensor-based Diagnostic Devices

Bioenno Lifesciences has been developing a novel class of biomedical devices and systems including surface acoustic wave based devices, label-free multiparametric biosensor platform, and portable cell culturing system for long-term cell viability. One particular focus is on the development of nanotechnology/biosensor based, hand-held, low-cost in vitro diagnostic devices (IVD) to rapidly detect biomarkers in human blood, breath, saliva, sweat, and urine that would bring universal hospital-grade diagnostic capabilities and emergency-care equipment to patients. Bioenno Lifesciences is advancing a novel class of hybrid biosensor for rapid evaluation of anticancer drug efficacy.

We can also provide the contract research on the design and prototype of biomedical devices in terms of customers’ requirement.  Below is a general overview of some of our recent and ongoing projects.

Major Patent-Pending Projects:

1) SAW-sensor based Breath Analysis and Diagnostic Device. A self-contained and self-sufficient advanced surface acoustic wave (SAW) sensor based portable point-of-care analysis system is currently being developed for the advanced diagnosis and detection of lung cancer in its early stages. This patent pending device is currently the only such apparatus in existence and is the first truly portable device of its kind. There is no other comparable device in its class that can offer our device’s capabilities.

2) SH-SAW-sensor based Real Time In-Vivo Trauma Induced Coagulopathy Monitoring Device. In conjunction with the lung cancer detection system, Bioenno Lifesciences is currently in development of a sheer horizontal-surface acoustic wave (SH-SAW) sensor based for the in-vivo monitoring of trauma induced coagulopathy (TIC) in patients in an intensive hemorrhagic state. Currently, this is the most advanced and only biomarker based real-time disposable sensory-catheter array device for blood born conditions, diseases, and disorders. This is something traditional systems and optical systems cannot match or offer.

3) An Integrated Hybrid Biosensor for Real-time Evaluation of Anticancer Drug Efficacy. Our team has developed a novel class of hybrid biosensor system that is integrated with a self-contained CO2 incubator unit. This hybrid biosensor system is aimed to use for rapid evaluation of the efficacy of anticancer drugs, for instance, to determine the chemosensitivity of existing anticancer drugs in order to achieve better personalized treatment for particular patients.

Other Projects:

1) Label Free and Real Time Biosensor with Multiparametric Detection We are currently developing a lab-on-chip biosensor for real-time, rapid, and sensitive detection of toxicants in drinking water. The high-content detection capability is realized by efficiently integrating two sensing methods in a single chip.

2) Portable Cell Culturing System of Long-term Cell Viability To develop a truly field portable cell based sensor, we are developing a miniaturized cell culture chip that has the capability of long-term maintaining cell viability automatically with low cell media consumption.

3)  High-Efficiency Adsorbent Sampling System Based on Mesoporous Oxide We are developing a high surface-area, mesoporous oxide adsorbent sampling system comprised of a standoff sensor that can be used for detecting both chemical vapors and biological aerosols. It will significantly reduce the logistics burden by reducing the number of sensors in the field.  A rugged and inexpensive chemical sensor will also benefit the manufacturing community by providing economical monitoring of chemical and biological processes.

4) Nanomaterials-based Biosensor  Our broad-based biosensor in development can be deployed in biological environments for real-time detection of agents of interest and for defense of potential hazards. Currently,there is a pressing need to develop a new class of biosensors capable of monitoring exposure to biological or chemical warfare agents for either acute or chronic conditions in living systems.  We seek to address this need through the employment of nanotechnology based biosensors.

5) Tailored Spot Heating and Fluid Transportation Bioenno Lifesciences is also developing a novel class of Tailored Spot Heating and Controllable Fluid Transportation Technology through the incorporation of microfluidics and lap-on-a-chip concepts for a number of potential applications in biomedical devices and systems.

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